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In a 2017 RCT by Chan et al, 40 lactoferrin in combination with zinc and vitamin E demonstrated a significant reduction in comedones, inflammatory lesions, and sebum production after 10 weeks of treatment

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Lipid peroxidation measurement by flow cytometry Lipid peroxidation was assessed in RA-differentiated SH-SY5Y cells after chronic (9 days) or acute (8 h) exposure to iron or BSO, alone or in combination with a short-term treatment of RSL-3 or H₂O₂